Activation of Type I and Type III Interferons in Chronic Hepatitis C
نویسندگان
چکیده
منابع مشابه
Activation of Type I and Type III Interferons in Chronic Hepatitis C.
Infection with hepatitis C virus (HCV) results in chronic and progressive liver disease. Persistency rates add up to 85%. Despite recognition of the virus by the human host in peripheral blood and in the liver, immune response appears to be ineffective in clearing infection. The ability to spontaneously eradicate the virus as well as the outcome of infection upon therapy with human recombinant ...
متن کاملType III Interferons in Hepatitis C Virus Infection
The interferon (IFN)-λ family of type III cytokines includes the closely related interleukin (IL)-28A (IFN-λ2), IL-28B (IFN-λ3), and IL-29 (IFN-λ1). They signal through the Janus kinases (JAK)-signal transducers and activators of transcription pathway and promote an antiviral state by the induction of expression of several interferon-stimulated genes (ISGs). Contrary to type I IFNs, the effect ...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy
The human interferon (IFN) response is a key innate immune mechanism to fight virus infection. IFNs are host-encoded secreted proteins, which induce IFN-stimulated genes (ISGs) with antiviral properties. Among the three classes of IFNs, type III IFNs, also called IFN lambdas (IFNLs), are an essential component of the innate immune response to hepatitis C virus (HCV). In particular, human polymo...
متن کاملProduction of type I interferons
Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. Here we discuss recent data that begin to reveal the unique...
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ژورنال
عنوان ژورنال: Journal of Innate Immunity
سال: 2015
ISSN: 1662-811X,1662-8128
DOI: 10.1159/000369973